Welcome to the ScotCRN website

ScotCRN (Scottish Children's Research Network) is funded by the Chief Scientist Office (CSO) in the Scottish Government and is tasked with supporting clinical research to improve the safety and efficacy of children's medicines and healthcare. We do this by providing the infrastructure in the form of Clinical Research Facilities at each children's hospital staffed by experienced paediatric research nurses and providing support in the set up, research governance and conduct of trials.


autoimmune diabetes Accelerator Prevention Trial (adAPT)

The launch of adAPT is happening on 20 April 2016. adAPT is a clinical study evaluating a new hypothesis that metformin, an inexpensive drug with a simple treatment regimen, can prevent type 1 diabetes. The trial will be opening in 10 Health Boards in Scotland supported by ScotCRN.

Initial funding of $1.7 million is being provided by JDRF, (juvenile diabetes research foundation) the leading global organisation backing type 1 diabetes research. The study aims to contact all 6,400 families in Scotland affected by the condition, with a view to expanding into England at a later date. Children aged 5 to 16 who have a sibling or parent with type 1 diabetes will be invited for a blood test to establish whether they are at high risk of developing the disease. If so, they will be invited to take part in the trial.

Researchers will then examine the impact of administering metformin, the world’s most commonly prescribed diabetes medicine, to young people in the high-risk category. If successful, the large-scale trial could explain why the incidence of type 1 diabetes has risen five-fold in the last 40 years, and

To find out more about the trial or to get involved, please visit www.adaptdiabetes.org



Health research: making the right decision for me

The Nuffield Council on Bioethics have worked with Mosaic Films to create a short animated film which conveys some of the key themes of the Council's new report 'Children and clinical research: ethical issues' from the perspective of Mia – a character who goes through some of the questions and issues that might be raised when a young person is invited to take part in clinical research. The script was developed following a workshop with 14 young people aged 10-18 who had previously been in contact with the Council, but were not ‘experts’ in clinical research.


The SEATON Study at Fifteen....The Movie

The SEATON study was designed to answer the question "Does mother's diet during pregnancy affect her unborn child's risk for getting asthma and allergies?"

2000 mothers were recruited between 1997 and 1999 and the study tracked them and their children until it closed in early 2015. This video tells the story....